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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
40.91
Human Site:
S220
Identified Species:
60
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
S220
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
S211
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
S220
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Dog
Lupus familis
XP_541736
1001
113024
S318
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
S220
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Rat
Rattus norvegicus
NP_001101343
905
102125
S221
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
S227
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Chicken
Gallus gallus
NP_001006139
888
100332
S207
N
V
F
K
E
R
I
S
D
M
C
K
E
N
R
Frog
Xenopus laevis
P55861
886
100243
S205
N
V
F
K
E
K
I
S
D
M
C
K
E
N
K
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
S207
N
V
F
K
E
R
I
S
D
M
C
K
E
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
R205
Y
T
Y
R
D
R
I
R
R
M
C
E
Q
N
M
Honey Bee
Apis mellifera
XP_395109
1005
114136
R324
Y
M
Y
K
E
R
I
R
H
M
C
E
S
N
Q
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
V156
V
K
I
S
G
I
I
V
A
A
A
Q
V
R
S
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
R205
N
V
Y
R
E
K
I
R
Q
M
C
E
G
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
P165
I
T
S
F
V
G
L
P
T
G
S
V
Y
P
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
R232
S
V
Y
G
A
R
I
R
T
L
G
E
M
N
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
86.6
93.3
N.A.
33.3
46.6
6.6
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
66.6
73.3
13.3
80
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
7
7
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
82
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
63
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
75
0
0
0
0
0
0
25
63
0
0
% E
% Phe:
0
0
63
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
7
7
0
0
0
7
7
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
7
0
7
0
0
7
94
0
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
69
0
13
0
0
0
0
0
63
0
0
19
% K
% Leu:
0
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
82
0
0
7
0
7
% M
% Asn:
69
0
0
0
0
0
0
0
0
0
0
0
0
88
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% P
% Gln:
0
0
0
0
0
0
0
0
7
0
0
7
7
0
7
% Q
% Arg:
0
0
0
13
0
75
0
25
7
0
0
0
0
7
50
% R
% Ser:
7
0
7
7
0
0
0
63
0
0
7
0
7
0
13
% S
% Thr:
0
13
0
0
0
0
0
0
13
0
0
0
0
0
7
% T
% Val:
7
75
0
0
7
0
0
7
0
0
0
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
13
0
25
0
0
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _